The Role of Compounding Pharmacies in Personalized Medicine

Mahshid Moghei, PhD Medically reviewed by Mahshid M. on | Written by Philip Lindeman MD-PhD

Pharmacist Providing Personalized Compounding Medication Solutions

Key Takeaways

  • Generic medications are more affordable, as they lack the research and development expenses associated with brand-name drugs.

  • Online pharmacies provide convenient access to medications, delivering prescriptions directly to patients’ homes.

  • Compounding pharmacies specialize in creating personalized medications tailored to individual patient needs, such as allergies or specific dosage requirements.

  • Consulting with a healthcare provider is crucial to determine the most suitable pharmacy option based on medical conditions and treatment goals.

  • Compounded medications offer a personalized approach for patients with complex or rare health conditions, ensuring safe and effective care.

Author’s note: The story's details below have been altered to protect the patient’s privacy.

A compound pharmacist helped me take care of Andrew, a 4-year-old patient who was at risk of becoming dehydrated.

Every winter, a so-called "stomach flu" sweeps through New England. The term is misleading, as it is not influenza, and the system affected is not the stomach. Instead, it refers to a group of viruses that cause nausea, vomiting, and diarrhea. These viruses can be particularly problematic for children, as their smaller bodies lose fluids more quickly than adults.

In my area, parents often rush their children to emergency rooms at the first signs of the stomach flu. This response is less than ideal, mainly because they risk spreading the virus to others in the waiting room. Moreover, the children are frequently treated with intravenous (IV) fluids, even though most cases can be managed through other methods. As the saying goes, "You go to Midas, you get a muffler; you go to the emergency room, you get an IV." Fortunately, these illnesses are typically short-lived, and most children recover without becoming dangerously dehydrated.

One day, Andrew's mother called, worried because he couldn’t keep any food or fluids down. She feared he might become dehydrated. I shared her concern but had a solution in mind.

A compounding pharmacist had provided me with samples of an anti-nausea medication that could be applied topically to the wrist in tiny amounts. The drug would be absorbed through the skin, eliminating the risk of Andrew vomiting it up. I had several syringes of this medicine in my office, and I had even used it myself earlier in the season after catching the bug from a patient.

The medication worked like a charm for Andrew. He was able to take small sips of fluid regularly and felt much better the next day.

Personalized Medicine in Action

Andrew’s story is a perfect example of the personalized care made possible through my partnership with a compounding pharmacy. Compounding pharmacies play a crucial role in customizing medications to meet the unique needs of each patient by adjusting dosage and strength. This is particularly valuable for pediatric and elderly patients, who often require smaller, more precise doses that aren’t available in standard medications. Additionally, compounding allows medications to be transformed from one form to another—such as converting an anti-nausea pill into a topical cream—making them easier for patients to take or apply. Compounding pharmacies also cater to patients with allergies or sensitivities by removing unwanted ingredients like dyes, gluten, or lactose, ensuring that treatments are both safe and effective.

The Patient-Centered Benefits of Compounding

Compounding pharmacies provide significant patient-centered benefits, especially for individuals with rare diseases or complex medical conditions who may not find suitable treatments in commercially available medications. These pharmacies address unique needs by creating custom formulations, tailoring medications to specific health challenges. This level of customization can also improve medication adherence, as pharmacists can modify a drug’s form, flavor, or dosage to make it easier and more convenient for patients. Additionally, compounding can offer potential cost savings, allowing patients to access personalized formulations that are often more affordable than brand-name alternatives.

Collaboration Between Healthcare Providers and Compounding Pharmacies

Collaboration between healthcare providers and compounding pharmacies is essential for delivering personalized therapies that meet each patient’s unique needs. Physicians and compounding pharmacists work together to create custom treatment plans, ensuring medications are precisely tailored in terms of dosage, form, and ingredient preferences. This partnership enables a more individualized approach to patient care. Additionally, compounding pharmacists play a key role in educating patients about their customized medications, explaining how to use them effectively, addressing any concerns, and ensuring patients understand both the benefits and potential adjustments in their treatment. This collaborative effort ultimately improves patient outcomes and overall satisfaction.

Compounding Pharmacies Versus Generics Available Online

Generic medications from online pharmacies offer several advantages over compounding pharmacies, particularly affordability and accessibility. These medications are often significantly cheaper than brand-name alternatives because they bypass the extensive research and development costs. Online pharmacies offer convenient access to a wide variety of generic medications, often delivering them directly to a patient’s doorstep, making it easier to maintain prescriptions without frequent pharmacy visits. Meanwhile, compounding pharmacies specialize in creating customized medications for patients with specific needs, such as allergies, unique dosage requirements, or rare conditions. Both options serve important purposes: generics provide affordable solutions for common conditions, while compounded medications offer highly personalized care.

Consulting with a healthcare provider is crucial when deciding between a compounding pharmacy, online pharmacy, or standard pharmacy, as each option addresses different patient needs. A healthcare provider can assess the patient’s medical condition, treatment goals, and any concerns—such as allergies, dosage requirements, or convenience—to recommend the best choice. For common conditions and cost-effective care, a standard or online pharmacy offering generics may suffice. However, a compounding pharmacy may be essential for individuals with unique health challenges, such as rare conditions or sensitivities to certain ingredients. By working closely with a healthcare provider, patients can make informed decisions that align with their treatment needs and lifestyle, ensuring safe, effective, and personalized care.

For Andrew, the best solution was through a compounding pharmacy. Every situation is different, so it’s important to consult your healthcare provider if you have any questions or concerns about treating a health problem.

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Sources

  1. Carvalho M, Almeida IF. The Role of Pharmaceutical Compounding in Promoting Medication Adherence. Pharmaceuticals (Basel). 2022 31;15(9):1091. doi: 10.3390/ph15091091.

  2. Heitman T, Day AJ, Bassani AS. Pediatric Compounding Pharmacy: Taking on the Responsibility of Providing Quality Customized Prescriptions. Children (Basel). 2019;6(5):66. doi: 10.3390/children6050066.

  3. MacArthur RB, Ashworth LD, Zhan K, Parrish RH 2nd. How Compounding Pharmacies Fill Critical Gaps in Pediatric Drug Development Processes: Suggested Regulatory Changes to Meet Future Challenges. Children (Basel). 202;9(12):1885. doi: 10.3390/children9121885.

  4. Watson CJ, Whitledge JD, Siani AM, Burns MM. Pharmaceutical Compounding: a History, Regulatory Overview, and Systematic Review of Compounding Errors. J Med Toxicol. 2021;17(2):197-217. doi: 10.1007/s13181-020-00814-3.


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The content on this page is for informational and educational purposes only and does not constitute professional medical advice. Patients should not use the information presented on this page for diagnosing a health-related issue or disease. Before taking any medication or supplements, patients should always consult a physician or qualified healthcare professional for medical advice or information about whether a drug is safe, appropriate or effective.