List of Natural Alternatives to Ozempic

Mahshid Moghei, PhD Medically reviewed by Mahshid M. on

Natural Weight Loss: Healthy lifestyle and Home Remedies

Ozempic (a GLP-1 semaglutide injection) gained in popularity due to its effective rate of shedding body weight. Patients on a 68-week period usually saw anywhere from a 5% to a 15% reduction in body weight. Leading to a large craze in the United States with more than 6% of Americans said to be on some type of GLP-1 injection for Type 2 diabetes.

While natural alternatives for weight loss are both going to take longer to see effects and need to be accompanied with dieting, the side effects are usually much lower and easier to manage compared to the pharmaceutical options for weight loss treatment.

Key Takeaways

  • Some of the more popular natural alternatives to Ozempic include Berberine, Psyllium Husk, and Apple Cider Vinegar options to help reduce body weight.

  • Most side effects that are experienced with natural remedies are very mild and/or rare. And don’t compare to the GLP-1 semaglutide injections onset and long-term side effects.

  • Natural remedies for weight loss will usually take longer and must be accompanied with strict dieting and exercise to see lasting results.

Natural Alternatives to Ozempic (List)

Here is a chart comparing some natural alternatives to Ozempic that are commonly associated with weight loss. The efficacy of these natural alternatives may vary depending on individual response, and it is important to consult with a healthcare provider before starting any supplement or weight loss plan:

Natural Alternative

Efficacy

Dosage Information

Potential Side Effects

Garcinia Cambogia

Some studies show modest weight loss (2-3 lbs over 12 weeks) due to appetite suppression and fat blocking

500-1000 mg 3 times daily (before meals)

Digestive issues, headache, dizziness, possible liver damage

Green Tea Extract

May increase fat burning and boost metabolism; small effect on weight loss (1-2 lbs) over time

250-500 mg daily (containing 50-80% catechins)

Nausea, insomnia, elevated heart rate, liver issues in rare cases

Glucomannan (Konjac Root)

Appetite suppressant, promotes fullness, leading to weight loss (3-4 lbs over 5 weeks)

1-2 grams before meals with water

Bloating, gas, diarrhea, potential choking hazard if not taken with enough water

Apple Cider Vinegar

May help with appetite control and blood sugar management; modest weight loss (~2-4 lbs over 12 weeks)

1-2 tablespoons diluted in water daily

Throat irritation, tooth enamel erosion, digestive discomfort

Berberine

Improves insulin sensitivity and may assist in weight loss (average 5 lbs in 12 weeks)

500 mg 2-3 times daily

Digestive issues, nausea, potential interactions with medications

Caffeine

Increases metabolism and promotes fat burning; associated with mild weight loss (1-2 lbs over time)

100-400 mg daily (from coffee, tea, or supplements)

Insomnia, jitteriness, elevated heart rate, dependency

CLA (Conjugated Linoleic Acid)

Some studies show minor weight loss (1-2 lbs) over several months, mainly from fat reduction

3.2-6.4 grams daily

Digestive upset, insulin resistance, increased inflammation

Fiber (Psyllium Husk, Inulin)

Helps control appetite and improve digestion, leading to modest weight loss

5-10 grams daily

Bloating, gas, cramping

Chromium Picolinate

Helps regulate blood sugar levels; minor effect on appetite control and weight loss (up to 1-2 lbs)

200-1000 mcg daily

Insomnia, mood swings, headaches

Probiotics

May influence gut bacteria and improve weight management, but results are inconsistent

Varies by strain, typically 1-10 billion CFUs daily

Bloating, gas, digestive upset

Other Pharmaceutical Alternatives to Ozempic

While the list above is mostly considered to be natural alternatives, other over-the-counter medications or “wonder drugs” have hit the market. That includes SeroLean, Instant Knockout Cut, and Metformin. All of which are more accessible than attempting to get an Ozempic prescription based on Type 2 diabetes.

GLP-1 injections are hitting the market with varying price tags. Hims/Hers (the brand) recently released both a GLP-1 injection of compounded semaglutide as well as a Metformin (oral tablet) treatment for weight loss.

These options are not considered to be natural alternatives. However, may be a more ‘accessible’ alternative for those who are looking for similar weight loss efficacy of that of Ozempic.

Why Berberine and Psyllium Husk Are Popular Alternatives

Berberine shows on average a 5lb weight loss over a 12-week period. Which is surprisingly good on its own. The oral tablet is easy to find both online and through natural medicine stores. And Psyllium Husk helps with cravings and that “starving” feeling that many patients want to treat.

Both Psyllium Husk and Berberine can be taken in combination to create similar effects to that of a semaglutide GLP-1 injection. However, it’s important to always combine these treatments with dieting and regular exercise.

Berberine tablets can be found for as low as $29.99 and to as high as $59.99 depending on the type of tablet and manufacturer that you choose. However, a fairly discounted and affordable option compared to Ozempic (semaglutide) pens being anywhere from $950 to $1,350 per pen or month’s supply

Common Questions

Questions about natural alternatives to Ozempic:

Will natural alternatives be as effective as Ozempic?

Unfortunately, no. However, there are many other added benefits to seeking natural remedies to treating your weight loss. That can include the reduced cost to treat weight loss. As well as preventing any short-term or long-term side effects that can come from GLP-1 injections.

Which drug is considered to be the “natural Ozempic?”

Right now that supplement is Berberine. Which is getting the name due to the 5lb average weight loss that consumers are seeing over a 12-week period.

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Sources

  1. Pharmacy Times. (2023, September 1). Survey: 1 in 8 adults have utilized a GLP-1 medication, 6% currently are. https://www.pharmacytimes.com/view/survey-1-in-8-adults-have-utilized-a-glp-1-medication-6-currently-are


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The content on this page is for informational and educational purposes only and does not constitute professional medical advice. Patients should not use the information presented on this page for diagnosing a health-related issue or disease. Before taking any medication or supplements, patients should always consult a physician or qualified healthcare professional for medical advice or information about whether a drug is safe, appropriate or effective.