Medically reviewed by 
The most common side effects of Methenamine Hippurate (Hiprex) are nausea, upset stomach, dysuria, rash, and bladder irritation. Methenamine Hippurate (Hiprex) is an antibiotic, but not the type that treats active infections or active UTIs (urinary tract infections). Instead, Methenamine Hippurate (Hiprex) helps prevent and control chronic UTIs (urinary tract infections) in people who need long-term treatment.
Key Takeaways
Methenamine Hippurate (Hiprex) is an antibiotic, but not the type that treats active infections or active UTIs (urinary tract infections).
The most common side effects of Methenamine Hippurate (Hiprex) are nausea, upset stomach, dysuria, rash, and bladder irritation.
Hiprex (Methenamine Hippurate) Side Effects
According to the FDA label, here are the common Hiprex (Methenamine Hippurate) side effects. According to the FDA label, “Minor adverse reactions have been reported in less than 3.5% of patients treated. These reactions have included nausea, upset stomach, dysuria, and rash.”
This can be broken down into the following data table:
Side Effect | Frequency |
Nausea | < 3.5% of patients |
Upset stomach | < 3.5% of patients |
Dysuria (painful urination) | < 3.5% of patients |
Rash | < 3.5% of patients |
Bladder irritation (with large doses) | Occasional, with higher doses (up to 8 grams daily). |
Preventing Common Side Effects of Hiprex (Methenamine Hippurate)
Hiprex (Methenamine Hippurate) thankfully doesn’t have a long list of side effects. However, here are the most common side effects and how to prevent them for occurring:
Nausea and Upset Stomach: These symptoms may occur, particularly when the medication is taken on an empty stomach. Taking Hiprex with food or at bedtime can help reduce these side effects.
Dysuria (Painful Urination): Some patients experience painful urination, especially when starting treatment. Maintaining adequate hydration and ensuring the urine stays acidic (as required for Hiprex to work properly) can help prevent or reduce discomfort.
Rash: A mild rash may develop in some individuals. If this occurs, consult with a healthcare provider for further guidance. Discontinuation or dosage adjustments may be required.
Bladder Irritation (with higher doses): High doses (such as those exceeding 8 grams per day) can lead to bladder irritation. This can cause symptoms like painful urination and blood in the urine (hematuria). To prevent this, it’s important to follow the prescribed dose carefully and avoid self-adjusting the dosage.
Hair Loss and Hiprex (Methenamine Hippurate)
There are no clinical studies that suggest hair loss is a side effect of taking the medication Hiprex (methenamine hippurate). If you’re experiencing signs of hair loss, contact your PCP (primary care physician) to learn why you may be having these unexpected results.
Weight Gain and Hiprex (Methenamine Hippurate)
There are no clinical studies that suggest weight gain is a side effect of taking the medication Hiprex (Methenamine Hippurate). If you’re experiencing issues with your body mass index increasing, contact your PCP (primary care physician) to learn why you may be having these unexpected results.
Additionally, loss of appetite can be considered a negative side effect of Hiprex (Methenamine Hippurate), which would potentially cause weight loss rather than weight gain.
Rely on PlanetDrugsDirect.com to Buy Online Hiprex
As a trusted prescription referral service, we offer important benefits whenever you order online. Each of our partner pharmacies and/or government-approved dispensaries is committed to providing the best experience possible of any online prescription referral service on the internet. We offer:
Low prices
Quick turn-around times
Generic and brand-name medications
Unparalleled customer service
Sources
Ingenus Pharmaceuticals, LLC. (2023). Methenamine hippurate tablet [package insert]. DailyMed. Retrieved from https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=4412d667-63f6-427e-a5c6-376a0e1e172d.
Noureldin, Y. A., Elkoushy, M. A., Andonian, S. (2017). Is it safe to prescribe ascorbic acid for urinary acidification in stone-forming patients with alkaline urine? Turkish Journal of Urology, 43(4), 444-450. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5503439/#!po=81.2500
Ovung, A., & Bhattacharyya, J. (2021). Sulfonamide drugs: Structure, antibacterial property, toxicity, and biophysical interactions. Biophysical Reviews, 13(2), 259-272. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8046889/
Related Articles
The Role of Compounding Pharmacies in Geriatric Medicine
Key TakeawaysCompounding pharmacies create custom medications for older adults.Individualized dosing reduces drug interaction risks.Compounding offers easier dosage options for those who...
Pharma CEOs Summoned: Showdown Over High Drug Prices
The United States Senate Committee on Health, Education, Labor, and Pensions (HELP) is addressing high prescription drug prices in the US. The Democratic HELP members, led by Chairman Bernie...
Why Is Healthcare So Expensive in the US?
If you're like most Americans, you've probably wondered, "Why is healthcare so expensive in the US?" Medical bills can pile up quickly with costly healthcare expenses like hospital fees and...
