Prescription required. Can not be split. Product of Australia. Shipped from Australia. Vagifem is also marketed internationally under the name Vagifem Low.
Prescription required. Can not be split. Product of UK/EU. Shipped from United Kingdom of Great Britain and Northern Ireland.
Vagifem (estradiol hemihydrate) is a prescription medication containing estradiol, which is a type of estrogen.
It is primarily used to treat symptoms of vaginal atrophy due to menopause. Vaginal atrophy can lead to vaginal dryness, irritation, and painful intercourse (dyspareunia).
Estradiol helps replenish estrogen levels in the vaginal tissues, reducing the symptoms associated with estrogen deficiency.
Brand name: Vagifem (generic name: estradiol hemihydrate).
Form: Vagifem is available in the form of vaginal tablets (inserted directly into the vagina).
To comply with Canadian International Pharmacy Association regulations you are permitted to order a 3-month supply or the closest package size available based on your personal prescription. read more
For vaginal atrophy due to menopause: The usual dose is one 10 mcg tablet inserted vaginally once a day for the first 2 weeks, then reduced to one tablet twice a week after that for maintenance therapy.
For postmenopausal women with a uterus, a progestogen (e.g., progesterone) is also commonly recommended to help reduce the risk of endometrial cancer associated with unopposed estrogen therapy.
Administration:
Insert the Vagifem tablet deep into the vagina, preferably at bedtime to reduce any discomfort.
Use the tablet with clean, dry hands. The kit will include an applicator for easier insertion.
Do not use Vagifem if the vaginal area is irritated or infected, unless directed by a healthcare provider.
Timing: For maximum effectiveness, follow your healthcare provider’s instructions on when and how often to use Vagifem.
Missed Dose: If you miss a dose, insert the tablet as soon as you remember. If it's nearly time for the next dose, skip the missed dose—do not double the dose.
Discontinuation: If you need to stop using Vagifem, consult your healthcare provider about the recommended timing.
Common Side Effects:
Vaginal irritation: Burning or itching after insertion.
Vaginal discharge: Some users may experience an increase in vaginal discharge.
Headache.
Nausea.
Breast tenderness or discomfort.
Fluid retention or swelling.
Hair loss.
Serious Side Effects:
Blood clots: Estradiol use, especially in high doses or long-term, may increase the risk of deep vein thrombosis (DVT), pulmonary embolism (PE), heart attack, or stroke.
Endometrial cancer: Prolonged use of estrogen can increase the risk of uterine (endometrial) cancer, especially in women who still have a uterus.
Breast cancer: Increased risk of breast cancer with long-term estrogen use.
Heart disease: Estradiol may increase the risk of heart disease, including heart attacks and strokes, in some women, particularly those with risk factors.
Liver problems: Yellowing of the skin or eyes (jaundice), dark urine, and upper stomach pain.
Mood changes: Increased risk of depression or anxiety.
Changes in thyroid hormone levels.
Rare Side Effects:
Allergic reactions: Rash, itching, or swelling of the face, lips, or throat.
Changes in vision: Blurred vision or eye problems.
High blood pressure: Hormone therapy can sometimes lead to increases in blood pressure.
It’s important to inform your healthcare provider immediately or consider emergency care if you notice:
Changes in vision or speech.
Severe headaches.
Severe pain in chest or legs.
Breast lumps.
Can I take Vagifem with other medications?
Vagifem (estradiol hemihydrate) can interact with certain medications, including other hormone therapies, blood thinners, and anticonvulsants. Always inform your healthcare provider about all the medications you're taking, including over-the-counter drugs and supplements.
Is it safe to drink alcohol while using Vagifem?
Moderate alcohol consumption is generally considered safe while using Vagifem (estradiol hemihydrate), but excessive drinking may increase the risk of side effects, especially related to the liver or blood pressure. Always follow your healthcare provider's advice regarding alcohol consumption.
How long does it take for Vagifem to start working?
Vagifem (estradiol hemihydrate) may take several days to a few weeks to start relieving symptoms of vaginal dryness and discomfort. Continued use is recommended in some instances. In general, hormone therapy is recommended for the lowest dose and the shortest duration possible.
Can I use Vagifem if I’m pregnant or breastfeeding?
Vagifem (estradiol hemihydrate) should not be used during pregnancy, as it may harm the fetus. It is also not recommended for breastfeeding, as estradiol may pass into breast milk. Consult your doctor if you're pregnant, planning to become pregnant, or breastfeeding.
Will Vagifem cause weight gain?
Weight gain is not a common side effect of Vagifem (estradiol hemihydrate), but hormonal therapies can sometimes cause water retention or changes in fat distribution. Talk to your healthcare provider if you notice significant or rapid changes in weight.
What should I do if I miss a dose of Vagifem?
If you miss a dose, insert the tablet as soon as you remember unless it's almost time for the next dose. Do not double the dose to make up for a missed dose.
Can Vagifem be used for long-term treatment?
Vagifem (estradiol hemihydrate) can be used for long-term management of vaginal atrophy, but regular follow-ups with your healthcare provider are recommended to monitor the effectiveness and minimize potential risks of prolonged estrogen use, such as an increased risk of breast or uterine cancer. In general, hormone therapy is recommended for the shortest duration possible to help manage the risk of side effects.
The content on this page is for informational and educational purposes only and does not constitute professional medical advice. Patients should not use the information presented on this page for diagnosing a health-related issue or disease. Before taking any medication or supplements, patients should always consult a physician or qualified healthcare professional for medical advice or information about whether a drug is safe, appropriate or effective.
