Hydrochlorothiazide: Uses, Dosage, Side Effects (Hydrochlorothiazide)

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It is a widely prescribed thiazide diuretic for treating high blood pressure and fluid retention associated with various medical conditions. It is essential to exercise caution and inform healthcare providers about any underlying health issues before taking this medication. This article aims to provide comprehensive information on Hydrochlorothiazide, including its uses, dosage, potential side effects, and drug interactions. By following prescribed dosages and regularly monitoring blood pressure, patients can benefit from the therapeutic effects of Hydrochlorothiazide while minimizing risks.

Key Takeaways

How should I take hydrochlorothiazide?

To ensure proper administration of Hydrochlorothiazide, it is essential to follow the prescribed dosage and carefully adhere to the directions provided by your healthcare provider. Hydrochlorothiazide should be taken exactly as directed by your doctor. It is typically taken once daily, either with or without food. It is important to take the medication at the same time each day to maintain consistent levels in your body. Do not skip doses or take more than the recommended amount without consulting your doctor. If you forget to take a dose, take it as soon as you remember. However, if it is close to the time for your next dose, skip the missed dose and continue with your regular dosing schedule. If you have any questions or concerns about how to take Hydrochlorothiazide, consult your healthcare provider for guidance.


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More common side effects

Common side effects of this medication include weakness, light headedness, severe pain in your upper stomach spreading to your back, nausea and vomiting, fever, chills, tiredness, mouth sores, skin sores, easy bruising, unusual bleeding, pale skin, cold hands and feet, shortness of breath, and electrolyte imbalance. These side effects may occur while taking Hydrochlorothiazide and should be reported to your healthcare provider if they persist or worsen. It is important to note that not all individuals will experience these side effects, and some may experience different side effects not listed here. If you have any concerns or questions about the side effects of Hydrochlorothiazide, it is recommended to consult with your healthcare provider for further guidance.

What should I avoid while taking Hydrochlorothiazide?

It is important to be cautious of certain activities and substances while taking Hydrochlorothiazide in order to avoid potential complications or interactions. First, it is advisable to avoid alcohol consumption as it can trigger and even exacerbate the side effects. Additionally, individuals taking Hydrochlorothiazide should prevent overheating or dehydration during exercise and hot weather. It is crucial to inform your doctor about all medications you are taking, including prescription, over-the-counter medications, vitamins, and herbal products, as there may be potential interactions. Furthermore, it is essential to follow the prescribed dosage and directions provided by your doctor. Regularly checking your blood pressure and reporting any ongoing vomiting, diarrhea, or excessive sweating to your doctor are also recommended. By being mindful of these precautions, you can ensure the safe and effective use of Hydrochlorothiazide in your treatment plan.

How to use Hydrochlorothiazide

When taking Hydrochlorothiazide, it is important to follow the prescribed instructions and dosage provided by call your doctor or healthcare provider. Hydrochlorothiazide is a medication used to treat high blood pressure and fluid retention. To ensure its effectiveness, it is crucial to take Hydrochlorothiazide as directed by your doctor. This includes following all directions on the prescription label and contacting your doctor if you experience ongoing vomiting, diarrhea, or excessive sweating. It is also important to regularly check your blood pressure while taking Hydrochlorothiazide. Store the medication at room temperature, away from moisture, heat, and freezing. Hydrochlorothiazide may cause certain side effects, such as weakness, nausea, and electrolyte imbalance. It is essential to be aware of these potential side effects and to consult your healthcare provider for personalized information and guidance.

What happens if I miss a dose?

If a dose of Hydrochlorothiazide is missed, it is important to take it as soon as possible, unless it is close to the next scheduled dose, in which case the missed dose should be skipped and the regular dosing schedule should be resumed. It is crucial to maintain a consistent medication regimen to effectively manage conditions such as high blood pressure and fluid retention. Skipping doses or taking them irregularly can lead to inadequate control of these conditions, potentially resulting in complications. Therefore, it is recommended to set reminders or establish a routine to ensure timely administration of Hydrochlorothiazide. Adhering to the prescribed dosing schedule will optimize the benefits of the medication and minimize the risk of adverse events. In the event of a missed dose, it is essential to resume the regular dosing schedule without doubling up on doses.

What happens if I overdose?

In the event of an overdose of Hydrochlorothiazide, it is crucial to seek immediate medical attention or contact emergency services. An overdose of this medication can lead to serious complications and may require prompt intervention. Symptoms of an overdose may include extreme dizziness, fainting, confusion, seizures, or severe weakness. It is important to note that taking more than 25 mg of the prescribed dose of Hydrochlorothiazide can be dangerous and should be avoided. To prevent accidental overdose, it is essential to follow the prescribed dosage instructions provided by your healthcare provider.

Dosage for high blood pressure

For the treatment of high blood pressure, the appropriate dosage of Hydrochlorothiazide is determined by the individual's healthcare provider based on factors such as their medical history and response to the medication. Hydrochlorothiazide is a commonly prescribed medication for managing high blood pressure, and it works by increasing the amount of urine produced, which helps to lower blood pressure. The dosage may vary depending on the severity of the condition and the individual's specific needs. It is important to follow the prescribed dosage and take the medication as directed by your healthcare provider. Additionally, regular check-ups and monitoring of blood pressure levels are essential to ensure the medication is effectively managing high blood pressure. If you have any concerns or questions about your dosage, it is best to consult with your healthcare provider for personalized guidance.

Dosage for Edema

The appropriate dosage of Hydrochlorothiazide for managing edema is determined by the individual's healthcare provider based on factors such as their medical history and response to the medication. Edema, or fluid retention, is a condition that can be caused by various underlying health issues, and the dosage of Hydrochlorothiazide will depend on the severity of the edema and the specific needs of the patient. It is important to follow the dosage instructions provided by the healthcare provider and not to exceed the prescribed amount. Taking the medication as directed can help reduce fluid buildup and alleviate symptoms of edema.

Description and Brand Names

Like most medications, Hydrochlorothiazide may be sold under several brand names depending on the region in which it is sold. In America, the product may be sold as Microzide, HydroDIURIL, Esidrix, Oretic, and Ezide. Although the actual name of the product may vary, the active ingredient is consistent throughout, varying only in product appearance and fillers, and each product falls under the thiazide diuretics drug class. It is best to check with a pharmacist when purchasing the product should any confusion arise from differing product names.

Drug Interactions

It is important to be aware of potential drug interactions when taking Hydrochlorothiazide, as certain medications can interact with it and cause adverse effects. Hydrochlorothiazide is a commonly prescribed medication used to treat high blood pressure and fluid retention. While it is generally safe and effective, it can interact with other medications, potentially leading to unwanted side effects. It is important to inform your healthcare provider about all the medications you are taking, including prescription, over-the-counter, vitamins, and herbal products. Some medications that can interact with Hydrochlorothiazide include opioid medication, sleeping pills, muscle relaxers, and medicine for anxiety or seizures. Additionally, there are specific drug interactions with cholestyramine, colestipol, insulin or oral diabetes medicine, alcohol, and lithium. By being aware of these potential interactions, patients can ensure the safe and effective use of Hydrochlorothiazide and minimize the risk of adverse effects.

Hydrochlorothiazide dosing information

When prescribing Hydrochlorothiazide, healthcare providers should consider the appropriate dosing information based on the individual's medical condition and response to treatment. Hydrochlorothiazide is typically taken once daily, either in the morning or in the evening, with or without food. The dosage may vary depending on the specific condition being treated, ranging from about 12.5 mg to 50 milligrams per day. It is important to follow the prescribed dosage and not exceed it without medical guidance. Regular monitoring of blood pressure and electrolyte levels is essential to ensure the effectiveness and safety of the treatment. It is crucial to consult with a healthcare provider for personalized dosing instructions and any concerns or questions regarding Hydrochlorothiazide therapy.

Hydrochlorothiazide side effects

Common side effects of this medication may include weakness, gastrointestinal symptoms, changes in electrolyte levels, and skin reactions. It is important to note that these side effects may vary from person to person. Weakness is a common side effect that may cause individuals to feel fatigued or lacking in energy. Gastrointestinal symptoms, such as nausea, vomiting, or diarrhea, may also occur. Changes in electrolyte levels, specifically potassium and sodium, can lead to imbalances that can affect various bodily functions. Lastly, skin reactions, such as rashes or itching, may occur in some individuals. It is essential to consult with a healthcare professional if any of these side effects persist or worsen.

Blood pressure drugs

Blood pressure drugs are an important component of managing hypertension and reducing the risk of cardiovascular disease. These medications are crucial in helping individuals maintain healthy blood pressure levels and prevent complications associated with high blood pressure. There are several types of blood pressure drugs available, including diuretics, beta-blockers, ACE inhibitors, and calcium channel blockers. Each of these medications works in different ways to lower blood pressure and improve overall cardiovascular health. It is essential for individuals to work closely with their healthcare provider to determine which blood pressure drug is most suitable for their needs. Adhering to the prescribed dosage and following lifestyle modifications, such as maintaining a healthy diet and regular exercise, can further enhance the effectiveness of these drugs in managing hypertension. By taking blood pressure drugs as directed, individuals can take control of their health and reduce the risk of cardiovascular disease.

Missed Dose

If a dose of Hydrochlorothiazide is missed, it is important to contact your healthcare provider for guidance on how to proceed. Missing a dose of Hydrochlorothiazide can affect its effectiveness in treating high blood pressure and fluid retention. Your healthcare provider will be able to provide you with specific instructions on whether to take the missed dose or wait until the next scheduled dose. It is important not to double up on doses to make up for a missed one, as this can increase the risk of side effects. Your healthcare provider may also advise you on any necessary adjustments to your dosing schedule to ensure optimal treatment outcomes. Always consult with your healthcare provider for personalized guidance, as they will have the best knowledge of your specific medical condition and treatment plan.

What other drugs will affect Hydrochlorothiazide?

It is important to be aware of potential drug interactions with Hydrochlorothiazide, as certain medications can have an impact on its effectiveness and may increase the risk of side effects. When taking Hydrochlorothiazide, it is crucial to inform tell your doctor or healthcare provider about all medications you are currently taking, including prescription, over-the-counter, vitamins, and herbal products. Some medications can worsen the side effects of Hydrochlorothiazide or interfere with its ability to lower blood pressure effectively. For example, taking Hydrochlorothiazide with drugs that make you light-headed can intensify this effect. It is also important to ask your doctor before using opioid medication, sleeping pills, muscle relaxers, or medicine for anxiety or seizures, as they can interact with Hydrochlorothiazide. Additionally, specific drug interactions have been identified with cholestyramine, colestipol, insulin or oral diabetes medicine, and lithium. Always consult your healthcare provider for personalized information and guidance regarding potential drug interactions with Hydrochlorothiazide.

Vision problems warning

One important warning associated with Hydrochlorothiazide is the increased risk of vision problems. While Hydrochlorothiazide is a commonly prescribed medication for treating high blood pressure and fluid retention, it is crucial to be aware of the potential side effect of vision problems. Some individuals may experience blurred vision, eye pain, or changes in their vision while taking Hydrochlorothiazide. If any of these symptoms occur, it is important to consult a healthcare professional promptly. Vision problems can be a serious concern, and it is essential to address them promptly to prevent any further complications. As a healthcare provider, it is crucial to educate and inform patients about this potential risk and advise them to seek medical attention if they experience any vision-related issues while taking Hydrochlorothiazide.

Incidence not known

The incidence of vision problems associated with Hydrochlorothiazide is not known. While it is generally well tolerated, there have been reports of vision-related side effects such as blurred vision and dry eyes. However, the exact frequency of these side effects is not known. It is important for individuals taking Hydrochlorothiazide to be aware of these potential vision problems and to promptly report any changes in their vision to their healthcare provider. Additionally, regular eye examinations should be conducted to monitor for any ocular changes. It is always recommended to consult with healthcare professionals for personalized information and to ensure the accuracy of the information provided.

Fluid and electrolyte imbalance warning

Fluid and electrolyte imbalance warning signs should be taken seriously when using Hydrochlorothiazide, and any symptoms such as muscle weakness, dizziness, or irregular heartbeat should be promptly reported to a healthcare provider. Fluid and electrolyte imbalances can occur when taking Hydrochlorothiazide so any related symptoms should not be ignored and should be promptly reported to a healthcare provider.

Warnings for people with certain health conditions

Individuals with underlying liver disease, kidney disease, glaucoma, asthma or allergies, gout, diabetes, or allergies to sulfa drugs or penicillin should inform their doctor before using Hydrochlorothiazide. It is important to disclose any pre-existing health conditions to ensure the safe and effective use of the medication. Hydrochlorothiazide is a thiazide diuretic commonly prescribed for high blood pressure and fluid retention. While it can be beneficial, it is important to be aware of potential risks and side effects. It is essential to follow the prescribed dosage and inform the doctor of any ongoing symptoms or changes in health. Additionally, individuals should avoid alcohol consumption and take precautions to prevent dehydration and overheating. Regular monitoring of blood pressure is important, and any concerns or questions should be discussed with a healthcare provider.

Frequently Asked Questions

Can I Take Hydrochlorothiazide With Other Blood Pressure Medications?

Yes, Hydrochlorothiazide can be taken with other blood pressure medications. However, it is important to consult with your healthcare provider to ensure proper dosage and monitor for any potential drug interactions or side effects.

Is It Safe to Take Hydrochlorothiazide if I Have Vision Problems?

It is important to consult your doctor before taking Hydrochlorothiazide if you have vision problems. They will assess the risks and benefits based on your specific condition and medical history to determine if it is safe for you to take the medication.

What Should I Do if I Miss a Dose of Hydrochlorothiazide?

If you miss a single dose, of Hydrochlorothiazide, take it as soon as you remember. However, if it is close to the time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for the missed one.

Are There Any Specific Health Conditions That I Should Be Aware of Before Taking Hydrochlorothiazide?

Before taking Hydrochlorothiazide, it is important to be aware of specific health conditions such as kidney or liver disease, glaucoma, gout, diabetes, and allergies to sulfa drugs or penicillin. Consult your doctor or pharmacist for personalized information.

What Are the Potential Risks of Fluid and Electrolyte Imbalance While Taking Hydrochlorothiazide?

Fluid and electrolyte imbalance is a potential risk associated with Hydrochlorothiazide. It can lead to heart failure due to symptoms such as weakness, light-headedness, and abnormal heart rhythms. Regular monitoring and proper hydration are important to prevent these complications.

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Hydrochlorothiazide Information

Hydrochlorothiazide



(hye'' droe klor'' oh thye' a zide)

Esidrix®¶
Hydrodiuril®¶
Microzide®
Oretic®
Zide®¶
Amturnide® (as a combination product containing Aliskiren, Amlodipine, Hydrochlorothiazide)
Apresazide® (as a combination product containing Hydralazine, Hydrochlorothiazide)
Accuretic® (as a combination product containing Quinapril, Hydrochlorothiazide)
Benicar® HCT (as a combination product containing Olmesartan, Hydrochlorothiazide)
Diovan® HCT (as a combination product containing Valsartan, Hydrochlorothiazide)
Dutoprol® (as a combination product containing Metoprolol, Hydrochlorothiazide)
Exforge® HCT (as a combination product containing Amlodipine, Hydrochlorothiazide, Valsartan)
Hydrap-ES® (as a combination product containing Hydralazine, Hydrochlorothiazide, Reserpine)
Hydro-Reserp® (as a combination product containing Hydrochlorothiazide, Reserpine)
Hydropres® (as a combination product containing Hydrochlorothiazide, Reserpine)
Hydroserp® (as a combination product containing Hydrochlorothiazide, Reserpine)
Hydroserpine® (as a combination product containing Hydrochlorothiazide, Reserpine)
Hydra-Zide® (as a combination product containing Hydralazine, Hydrochlorothiazide)
Inderide® (as a combination product containing Hydrochlorothiazide, Propranolol)
Inderide® LA (as a combination product containing Hydrochlorothiazide, Propranolol)
Lopressor® HCT (as a combination product containing Metoprolol, Hydrochlorothiazide)
Mallopress® (as a combination product containing Hydrochlorothiazide, Reserpine)
Marpres® (as a combination product containing Hydralazine, Hydrochlorothiazide, Reserpine)
Monopril® HCT (as a combination product containing Fosinopril, Hydrochlorothiazide)
Normozide® (as a combination product containing Labetalol, Hydrochlorothiazide)¶
Quinaretic® (as a combination product containing Quinapril, Hydrochlorothiazide)
Ser-Ap-Es® (as a combination product containing Hydralazine, Hydrochlorothiazide, Reserpine)
Serathide® (as a combination product containing Hydralazine, Hydrochlorothiazide, Reserpine)
Serpazide® (as a combination product containing Hydralazine, Hydrochlorothiazide, Reserpine)
Serpex® (as a combination product containing Hydralazine, Hydrochlorothiazide, Reserpine)
Tekturna® HCT (as a combination product containing Aliskiren, Hydrochlorothiazide)
Teveten® HCT (as a combination product containing Eprosartan, Hydrochlorothiazide)
Timolide® (as a combination product containing Timolol, Hydrochlorothiazide)
Trandate HCT® (as a combination product containing Labetalol, Hydrochlorothiazide)¶
Tri-Hydroserpine® (as a combination product containing Hydralazine, Hydrochlorothiazide, Reserpine)
Tribenzor® (as a combination product containing Amlodipine, Hydrochlorothiazide, Olmesartan)
Uni Serp® (as a combination product containing Hydralazine, Hydrochlorothiazide, Reserpine)
Unipres® (as a combination product containing Hydralazine, Hydrochlorothiazide, Reserpine)
Uniretic® (as a combination product containing Moexipril, Hydrochlorothiazide)
Ziac® (as a combination product containing Bisoprolol, Hydrochlorothiazide)

Hydrochlorothiazide is used alone or in combination with other medications to treat high blood pressure. Hydrochlorothiazide is used to treat edema (fluid retention; excess fluid held in body tissues) caused by various medical problems, including heart, kidney, and liver disease and to treat edema caused by using certain medications including estrogen and corticosteroids. Hydrochlorothiazide is in a class of medications called diuretics ('water pills'). It works by causing the kidneys to get rid of unneeded water and salt from the body into the urine.
High blood pressure is a common condition and when not treated, can cause damage to the brain, heart, blood vessels, kidneys and other parts of the body. Damage to these organs may cause heart disease, a heart attack, heart failure, stroke, kidney failure, loss of vision, and other problems. In addition to taking medication, making lifestyle changes will also help to control your blood pressure. These changes include eating a diet that is low in fat and salt, maintaining a healthy weight, exercising at least 30 minutes most days, not smoking, and using alcohol in moderation.

Hydrochlorothiazide comes as a tablet, capsule, and solution (liquid) to take by mouth. It usually is taken once or twice a day. When used to treat edema, hydrochlorothiazide may be taken daily or only on certain days of the week. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take hydrochlorothiazide exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor.
Hydrochlorothiazide controls high blood pressure but does not cure it. Continue to take hydrochlorothiazide even if you feel well. Do not stop taking hydrochlorothiazide without talking to your doctor.

Before taking hydrochlorothiazide,

tell your doctor and pharmacist if you are allergic to hydrochlorothiazide, sulfonamide antibiotic medications, penicillin, or any other drugs.

tell your doctor and pharmacist what other prescription and nonprescription medications, vitamins, nutritional supplements, and herbal products you are taking or plan to take. Be sure to mention any of the following: barbiturates such as phenobarbital and secobarbital (Seconal); corticosteroids such as betamethasone (Celestone), budesonide (Entocort), cortisone (Cortone), dexamethasone (Decadron, Dexpak, Dexasone, others), fludrocortisone (Florinef), hydrocortisone (Cortef, Hydrocortone), methylprednisolone (Medrol, Meprolone, others), prednisolone (Prelone, others), prednisone (Deltasone, Meticorten, Sterapred, others), and triamcinolone (Aristocort, Azmacort); corticotropin (ACTH, H.P., Acthar Gel); insulin and oral medications for diabetes; lithium (Eskalith, Lithobid); medications for high blood pressure or pain; nonsteroidal anti-inflammatory drugs (NSAIDs) such as ibuprofen (Advil, Motrin, others) and naproxen (Aleve, Naprosyn, others). Your doctor may need to change the doses of your medications or monitor you carefully for side effects.

if you are taking cholestyramine or colestipol, take them 1 hour before or 4 hours after taking hydrochlorothiazide.

tell your doctor if you have kidney disease. Your doctor may tell you not to take hydrochlorothiazide.

tell your doctor if you have or have ever had diabetes, asthma. gout, systemic lupus erythematosus (SLE, a chronic inflammatory condition), high cholesterol, or liver disease.

tell your doctor if you are pregnant, plan to become pregnant, or are breastfeeding. If you become pregnant while taking hydrochlorothiazide, call your doctor immediately.

plan to avoid unnecessary or prolonged exposure to sunlight and to wear protective clothing, sunglasses, and sunscreen. Hydrochlorothiazide may make your skin sensitive to sunlight.

you should know that hydrochlorothiazide may cause dizziness, lightheadedness, and fainting when you get up too quickly from a lying position. This is more common when you first start taking hydrochlorothiazide. To avoid this problem, get out of bed slowly, resting your feet on the floor for a few minutes before standing up. Alcohol can add to these side effects.

If your doctor prescribes a low-salt or low-sodium diet, or to eat or drink increased amounts of potassium-rich foods (e.g., bananas, prunes, raisins, and orange juice) in your diet, follow these instructions carefully.

Take the missed dose as soon as you remember it. However, if it is almost time for your next dose, skip the missed dose and continue your regular dosing schedule. Do not take a double dose to make up for a missed one.

Tell your doctor if any of these symptoms are severe or do not go away:



frequent urination

diarrhea

loss of appetite

headache

hair loss

If you experience any of the following symptoms, call your doctor immediately or get emergency medical treatment:



dry mouth; thirst; nausea; vomiting; weakness, tiredness; drowsiness; restlessness; confusion; muscle weakness, pain, or cramps; fast heartbeat and other signs of dehydration and electrolyte imbalance

blisters or peeling skin

hives

rash

itching

difficulty breathing or swallowing

fever, sore throat, chills, and other signs of infection

unusual bleeding or bruising

ongoing pain that begins in the stomach area, but may spread to the back

joint pain or swelling

changes in vision, eye pain, or swelling or redness in or around the eye
If you experience a serious side effect, you or your doctor may send a report to the Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting program online (http://www.fda.gov/Safety/MedWatch) or by phone (1-800-332-1088).

Keep this medicine in the container it came in, tightly closed, and out of reach of children. Store it at room temperature and away from excess heat and moisture (not in the bathroom). Do not allow the liquid to freeze.
Unneeded medications should be disposed of in special ways to ensure that pets, children, and other people cannot consume them.  However, you should not flush this medication down the toilet. Instead, the best way to dispose of your medication is through a medicine take-back program. Talk to your pharmacist or contact your local garbage/recycling department to learn about take-back programs in your community.  See the FDA's Safe Disposal of Medicines website (http://goo.gl/c4Rm4p) for more information if you do not have access to a take-back program.

Keep all appointments with your doctor and the laboratory. Your blood pressure should be checked regularly, and blood tests should be done occasionally.
Before having any laboratory test, tell your doctor and the laboratory personnel that you are taking hydrochlorothiazide.
Do not let anyone else take your medicine. Ask your pharmacist any questions you have about refilling your prescription.
It is important for you to keep a written list of all of the prescription and nonprescription (over-the-counter) medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. It is also important information to carry with you in case of emergencies.
¶ This branded product is no longer on the market. Generic alternatives may be available.

The content on this page is for informational and educational purposes only and does not constitute professional medical advice. Patients should not use the information presented on this page for diagnosing a health-related issue or disease. Before taking any medication or supplements, patients should always consult a physician or qualified healthcare professional for medical advice or information about whether a drug is safe, appropriate or effective.