Bupropion to Aid Smoking Cessation

Mahshid Moghei, PhD Medically reviewed by Mahshid M. on | Written by Philip Lindeman MD-PhD

5 min read

Contemplating Change: The Journey to Quit Smoking

Key Takeaways

  • Smoking cessation requires a combination of medication, behavioral techniques, and support.

  • Identifying triggers and adopting healthy habits are essential for long-term success.

  • Bupropion can help reduce cravings and withdrawal symptoms during smoking cessation.

  • Support from family, friends, and counseling groups increases motivation and success.

  • Regular exercise, a balanced diet, and stress management improve overall well-being during the quit process.

Mark is a 49-year-old man who has been smoking for over 30 years. He began as a teenager and, despite multiple attempts to quit, always found himself relapsing during stressful periods. Mark smoked about a pack a day and frequently experienced shortness of breath, particularly when climbing stairs. His family had expressed concerns about his health, and he was finally ready to commit to quitting for good.

In addition to his smoking, Mark had high blood pressure and was overweight. He also had a mild case of chronic bronchitis, which caused frequent coughing, especially in the mornings. I cautioned him that continued smoking could lead to more serious lung conditions.

During his annual check-up, I observed the following:

  • Blood pressure: 140/90 mmHg (elevated)

  • Heart rate: 80 beats per minute

  • Lungs: Wheezing heard in both lungs, more noticeable during coughing episodes

  • Weight: 210 pounds (overweight for his height)

I recommended a comprehensive approach combining medication and behavioral changes to support Mark in his effort to quit smoking.

Medication

Bupropion – This prescription medication helps reduce nicotine cravings and withdrawal symptoms. Mark started taking it daily, as I directed.

Behavioral Modification

Behavioral modification helps smokers break the habit by identifying triggers and developing healthier responses. Common techniques include avoiding smoking cues, such as coffee or alcohol, and replacing smoking with activities like chewing gum or practicing deep breathing. Setting a quit date and tracking progress can increase commitment.

Support from family, friends, or counseling groups can significantly improve motivation. Stress management strategies, such as exercise or meditation, help prevent relapse. Rewarding oneself for reaching milestones reinforces positive behavior. Behavioral therapy, including cognitive-behavioral strategies, teaches effective coping skills to resist cravings. Combining these behavioral techniques with medical treatment greatly increases the likelihood of successfully quitting and maintaining a smoke-free life.

Mark worked with a counselor to identify his smoking triggers, including stress, drinking coffee, and driving. He adopted new habits, such as chewing gum instead of smoking and taking walks when he felt the urge to smoke.

The Role of Support Systems in Smoking Cessation

Support systems play a crucial role in quitting smoking by offering encouragement, accountability, and motivation. Family and friends can provide emotional support and remind individuals of their reasons for quitting. Support groups, whether in-person or online, connect people with others facing similar challenges, fostering shared experiences and coping strategies. Counseling, including behavioral therapy, helps address triggers and cravings. Healthcare providers can offer guidance, monitor progress, and adjust treatments as needed. “Quitlines” and mobile apps provide additional resources and motivation. A strong support system significantly increases the chances of successfully quitting and maintaining a smoke-free lifestyle.

Mark shared his plan with family and friends so they could offer encouragement. He also joined a local smoking cessation group.

Healthy Lifestyle Changes in Smoking Cessation

Adopting a healthy lifestyle supports smoking cessation by reducing cravings, managing withdrawal symptoms, and improving overall well-being. Regular exercise helps relieve stress, boosts mood, and minimizes weight gain associated with quitting. A balanced diet rich in fruits, vegetables, and whole grains stabilizes blood sugar levels and supports lung and heart health. Staying hydrated helps flush nicotine from the body. Practicing stress management techniques, such as meditation or deep breathing, reduces anxiety and the urge to smoke. Adequate sleep enhances self-control and energy levels. Combining these healthy habits with smoking cessation efforts increases the likelihood of long-term success and overall wellness.

Mark began exercising for 30 minutes daily and replaced unhealthy snacks with high-protein options and vegetables to help manage his weight.

Outcome and Follow-Up

After three months, Mark had completely quit smoking. His follow-up appointment revealed significant improvements:

  • No longer coughing in the morning

  • Blood pressure reduced to 125/80 mmHg

  • Increased energy and less shortness of breath

  • Saved hundreds of dollars by not purchasing cigarettes

Mark continued using behavioral techniques to stay smoke-free and felt proud of his progress. Quitting wasn’t easy, but with the right tools and support, he was able to break free from smoking and improve his health for good.

Precautions and Contraindications for Bupropion

Bupropion should not be used by individuals with a history of seizures, eating disorders (such as anorexia or bulimia), or those undergoing abrupt alcohol or sedative withdrawal, as it increases the risk of seizures. It is also contraindicated in patients with a known allergy to bupropion. Those taking monoamine oxidase inhibitors should wait at least 14 days before starting bupropion. Patients with uncontrolled high blood pressure should use it with caution. Possible side effects include insomnia, dry mouth, and anxiety. Always consult a doctor before use, especially if taking other medications or if you have a history of mental health conditions.

Mark’s story demonstrates that quitting smoking is possible with the right support. If you or someone you know is ready to quit, consult a licensed healthcare provider about treatment options.

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Sources

  1. Zwar NA. Smoking cessation. Aust J Gen Pract. 2020 Aug;49(8):474-481. doi: 10.31128/AJGP-03-20-5287.

  2. Nian T, Guo K, Liu W, et al. Non-pharmacological interventions for smoking cessation: analysis of systematic reviews and meta-analyses. BMC Med. 2023 Sep 29;21(1):378. doi: 10.1186/s12916-023-03087-z.

  3. Kock L, Brown J, Hiscock R, et al. Individual-level behavioural smoking cessation interventions tailored for disadvantaged socioeconomic position: a systematic review and meta-regression. Lancet Public Health. 2019 Dec;4(12):e628-e644. doi: 10.1016/S2468-2667(19)30220-8.

  4. Chen D, Wu LT. Smoking cessation interventions for adults aged 50 or older: A systematic review and meta-analysis. Drug Alcohol Depend. 2015 Sep 1;154:14-24. doi: 10.1016/j.drugalcdep.2015.06.004.

  5. Rahimi F, Massoudifar A, Rahimi R. Smoking cessation pharmacotherapy; varenicline or bupropion? Daru. 2024 Dec;32(2):901-906. doi: 10.1007/s40199-024-00539-6.

  6. Vogeler T, McClain C, Evoy KE. Combination bupropion SR and varenicline for smoking cessation: a systematic review. Am J Drug Alcohol Abuse. 2016 Mar;42(2):129-39. doi: 10.3109/00952990.2015.1117480.

  7. Tong EK, Carmody TP, Simon JA. Bupropion for smoking cessation: a review. Compr Ther. 2006 Spring;32(1):26-33. doi: 10.1385/comp:32:1:26.


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