
Contrave (Bupropion Hydrochloride/Naltrexone Hydrochloride) is a prescription weight-loss medication that combines bupropion and naltrexone to assist in appetite control and cravings. It is approved for overweight and obese adults who have weight-related medical conditions, such as high blood pressure, diabetes, or high cholesterol. Contrave should be used in conjunction with a reduced-calorie diet and increased physical activity.
Contrave (Bupropion Hydrochloride/Naltrexone Hydrochloride) is not approved to treat high blood pressure, diabetes, or high cholesterol directly, nor is it indicated for depression, smoking cessation, or other psychiatric conditions.
Key Takeaways
Medical Use and Effectiveness: Contrave (Bupropion/Naltrexone) is a prescription weight-loss medication for overweight and obese adults with weight-related health conditions. It aids in appetite control but must be used alongside a reduced-calorie diet and increased physical activity. It is not approved for treating high blood pressure, diabetes, or psychiatric conditions.
Availability and Pricing: Contrave can be purchased online from various pharmacies, with bulk pricing available at PlanetDrugsDirect ($622.99 for 336 tablets) and DrugMart ($593.19 for 336 tablets). Amazon Pharmacy offers lower prices with insurance, while Sesame Care and PlushCare provide telehealth consultations for prescription access.
Safety and Precautions: Common side effects include nausea, headaches, and insomnia, while severe risks include seizures, mood changes, and liver issues. Contrave should not be used by individuals with seizure disorders, opioid dependency, or eating disorders. Alcohol and high-fat meals should be avoided, and pregnant women should not use the medication.
5 Places to Buy Contrave Online
Here are the 5 best places to purchase Contrave (Bupropion Hydrochloride/Naltrexone Hydrochloride) online:
Pharmacy | Price | Quantity & Strength | Notes |
$622.99 ($1.85 per tablet) | 336 tablets (90mg/8mg) | Trusted CIPA-certified online pharmacy | |
DrugMart.com | $593.19 | 336 tablets (90mg/8mg) | Best price for bulk purchases |
Amazon Pharmacy | $72 with insurance / $111.47 without insurance | 30 tablets (90mg/8mg) | Convenient, but costlier for long-term use |
Sesame Care | Price Varies | Varies | Includes telehealth consultations |
PlushCare | Price Varies | Varies | Requires an online consultation |
Prices updated March 2025.
Where to Buy Contrave Online
Where to buy Contrave (Bupropion Hydrochloride/Naltrexone Hydrochloride) online:
1. PlanetDrugsDirect – Trusted International Pharmacy Option
Price: $622.99 for 336 tablets (90mg/8mg) ($1.85 per tablet)
Why Choose PlanetDrugsDirect?
A CIPA-certified pharmacy, ensuring safe and legitimate medication.
Competitive pricing for bulk purchases of Contrave.
Suitable for patients looking for a reputable international provider.
Ready to purchase? Buy from PlanetDrugsDirect
2. DrugMart.com – Best Overall Price for Bulk Orders
Price: $593.19 for 336 tablets (90mg/8mg)
Why Choose DrugMart.com?
Offers the lowest price per tablet for Contrave in bulk.
Convenient online ordering with secure prescription verification.
Reliable shipping and consistent medication availability.
3. Amazon Pharmacy – Best for Insurance Holders
Price: $72 with insurance / $111.47 without insurance (30 tablets)
Why Choose Amazon Pharmacy?
Accepts insurance, making it a cost-effective choice for covered patients.
Offers automated refills and home delivery.
Ideal for those who need a short-term supply rather than bulk orders.
4. Sesame Care – Telehealth Consultation & Prescription
Price: Varies
Why Choose Sesame Care?
Provides telemedicine services for patients without a prescription.
Offers virtual consultations for weight management.
May include discounted medication options through partner pharmacies.
5. PlushCare – Integrated Prescription & Telemedicine Service
Price: Varies
Why Choose PlushCare?
Includes virtual medical consultations with licensed providers.
Allows patients to obtain a prescription for Contrave online.
Offers flexibility in prescription fulfillment.
Dosage
Contrave (Bupropion Hydrochloride/Naltrexone Hydrochloride) should be taken exactly as prescribed by a physician. The standard dosing regimen typically follows a titration schedule to reduce the risk of side effects.
Week 1: Take one tablet in the morning.
Week 2: Take one tablet in the morning and one in the evening.
Week 3: Take two tablets in the morning and one in the evening.
Week 4 and beyond: Take two tablets in the morning and two in the evening (maximum 4 tablets per day).
Important considerations:
Do not crush, chew, or break the tablets; swallow them whole.
Do not take with high-fat meals, as this can increase the risk of seizures.
If no significant weight loss (at least 5% of body weight) occurs within 12 weeks, your doctor may discontinue treatment.
If a dose is missed, skip it and take the next dose at the scheduled time. Do not take extra doses to make up for a missed dose.
Storage
Store Contrave (Bupropion Hydrochloride/Naltrexone Hydrochloride) at room temperature between 68°F and 77°F (20°C to 25°C).
Keep the medication away from moisture, heat, and direct light.
Do not store it in the bathroom, where humidity can affect the drug’s stability.
Keep Contrave out of reach of children and pets.
Dispose of unused or expired medication following local pharmacy or FDA guidelines.
Side Effects
As with any medication, Contrave can cause side effects, ranging from mild to severe.
Serious Side Effects (Seek Immediate Medical Attention)
Cardiovascular concerns: Severe headache, blurred vision, fast or irregular heartbeat, or pounding sensation in the neck or ears.
Neurological issues: Seizures, severe mood changes, panic attacks, suicidal thoughts, or unusual risk-taking behavior.
Liver problems: Upper stomach pain, dark urine, jaundice (yellowing of the skin or eyes).
Severe allergic reactions: Fever, swollen glands, mouth sores, trouble breathing, or swelling of the face, lips, or throat.
Common Side Effects
Gastrointestinal issues: Nausea, vomiting, diarrhea, constipation.
Neurological symptoms: Headache, dizziness, or trouble sleeping (insomnia).
Dry mouth or changes in taste.
Older adults may be more prone to side effects and should be monitored closely. If any unusual symptoms occur, patients should contact their healthcare provider immediately.
Precautions
Do not take Contrave (Bupropion Hydrochloride/Naltrexone Hydrochloride) if you have uncontrolled high blood pressure, seizure disorders, eating disorders (anorexia or bulimia), opioid addiction, or are taking opioid medications.
Contrave (Bupropion Hydrochloride/Naltrexone Hydrochloride) should not be used with other forms of bupropion, such as Wellbutrin or Zyban.
Patients should not consume alcohol while taking Contrave, as this may increase the risk of seizures.
Pregnant women should not use Contrave, as weight loss during pregnancy may harm the developing fetus.
For any concerns regarding Contrave (Bupropion Hydrochloride/Naltrexone Hydrochloride) use, side effects, or potential drug interactions, patients should consult their physician before starting or discontinuing treatment.
Rely on PlanetDrugsDirect.com to Buy Online Contrave
As a trusted prescription referral service, we offer important benefits whenever you order online. Each of our partner pharmacies and/or government-approved dispensaries is committed to providing the best experience possible of any online prescription referral service on the internet. We offer:
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Sources
U.S. Food and Drug Administration. Contrave (Naltrexone HCl and Bupropion HCl) Prescribing Information. Available at: https://www.accessdata.fda.gov/drugsatfda_docs/label/2021/200063s020lbl.pdf. Accessed March 7, 2025.